Severe hyperbilirubinemia can cause bilirubin-induced neurological dysfunction (BIND) and, if not treated adequately, may lead to acute and chronic bilirubin encephalopathy. Preterm infants and those born with congenital enzyme deficiencies are particularly prone to the harmful effects of unconjugated bilirubin on the central nervous system. The etiology of pathological UHB and CHB is vast and varied. Unconjugated hyperbilirubinemia (UHB) is the cause of clinical jaundice in most neonates, but some infants with jaundice have conjugated hyperbilirubinemia (CHB), which is always pathological and signifies an underlying medical or surgical cause. In most cases, it is a mild, transient, and self-limiting condition and resolves without treatment referred to as "physiological jaundice." However, it is imperative to distinguish this from a more severe form called "pathological jaundice." Failure to identify and treat this entity may result in bilirubin encephalopathy and associated neurological sequelae. Approximately 60% of term and 80% of preterm newborns develop clinical jaundice in the first week after birth. It is the most commonly encountered medical problem in the first two weeks of life and a common cause of readmission to the hospital after birth. ![]() The term jaundice derives from the French word "jaune," which means yellow. 10.1097/MEG.Neonatal jaundice or neonatal hyperbilirubinemia results from elevated total serum bilirubin (TSB) and clinically manifests as yellowish discoloration of the skin, sclera, and mucous membrane. Modulation of gut barrier function in patients with obstructive jaundice using probiotic LP299v. Observation of curative effect by microecologics combined with blue light irradiation in the treatment of neonatal jaundice. Italian guidelines for the management and treatment of neonatal cholestasis. 10.1101/cshperspect.a010074Ĭarlo D., Simone P., Francesco R., Costantino R. Probiotics: properties, examples, and specific applications. Probiotics for the management of hyperbilirubinemia in preterm neonates. M., Barekatain B., Hoseinzadeh M., Salehimehr N. Meta-analysis neonatal jaundice probiotics systematic review.Īrmanian A. Conclusion: This meta-analysis shows that probiotics supplementation therapy is an effective and safe treatment for pathological neonatal jaundice. Additionally, no serious adverse reaction was reported. It not only decreased the total serum bilirubin level after 3day, 5day, 7day treatment, but also decreased time of jaundice fading, as well as the duration of phototherapy and hospitalization, when compared with the control group. Probiotics supplementation treatment showed efficacy in neonatal jaundice. Results: 13 RCTs involving 1067 neonatal with jaundice were included in the meta-analysis. The relative risks (RR) or mean difference (MD) with a 95% confidence interval (CI) was used to measure the effect. The main outcomes of the trials were analyzed by Review Manager 5.3 software. The extracted information of RCTs should include efficacy rate, serum total bilirubin level, time of jaundice fading, duration of phototherapy, duration of hospitalization, adverse reactions. ![]() The cochrane tool was applied to assessing the risk of bias of the trials. Randomized controlled trials (RCTs) of probiotics supplementation for pathological neonatal jaundice in publications were extracted by two reviewers. Methods: Databases including PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure (CNKI), Wan Fang Database (Wan Fang), Chinese Biomedical Literature Database (CBM), VIP Database for Chinese Technical Periodicals (VIP) were searched and the deadline is December 2016. Therefore, this study aims at systematically evaluating the efficacy and safety of probiotics supplement therapy for pathological neonatal jaundice. ![]() However, there is limited evidence regarding the effect of probiotics on bilirubin level in neonates. Probiotics supplementation therapy could assist to improve the recovery of neonatal jaundice, through enhancing immunity mainly by regulating bacterial colonies. Background: Neonatal jaundice is a relatively prevalent disease and affects approximately 2.4-15% newborns.
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